NACE Prenatal Test – The Safe Alternative to Amniocentesis

NACE Prenatal Test – The Safe Alternative to Amniocentesis

Every expectant parent or mother would want to experience a relaxing and healthy pregnancy. Not to mention the prime concern being the baby’s health before and after birth. Do you also want to attain such an experience? Well being aware and well-read about the challenges during pregnancy would be the key.

Regular consultation with your doctor is the starter. Doctors would advise screening tests right from the first trimester. Trimester screenings are usually a combination of ultrasounds and blood testing. In some cases it may include other tests as well. The purpose of these tests is to determine the possibility of birth defects in your baby.

There are many tests that detect chromosomal abnormalities in the fetus, two of them being NACE prenatal test and amniocentesis. The latter is a conventional and common procedure and is invasive. NACE prenatal test is an outcome of new age technology which is completely non- invasive and proves to be a safe alternative to amniocentesis.

What are Chromosomal Abnormalities?

Human beings have 23 pairs of chromosomes, a total of 46 (two copies for each pair). The first 22 pairs are numbered 1 to 22. The 23rd pair determines the sex of the child. Girls have two X chromosomes (XX) and boys have an X and a Y chromosome (XY). If there is an extra copy of a chromosome (three copies instead of two) it is referred to as trisomy. A trisomy is a chromosomal abnormality and causes health and development problems in the fetus.

Pre natal tests primarily detect the following chromosomal abnormalities in fetuses.

  • Trisomy 21 (Down’s syndrome)
  • Trisomy 18 (Edward’s syndrome)
  • Trisomy 13 (Patau’s syndrome)
  • Trisomy in sex chromosomes (XXX, XXY and XYY)

How Are These Tests Performed?

In the case of amniocentesis, a sample of amniotic fluid is extracted from the mother’s womb. The fluid contains cells shed by the fetus that carry genetic information from which fetal chromosomal disorders could be diagnosed. Generally amniocentesis would constitute the below procedures.

  • The woman’s abdomen is cleansed with an antiseptic.
  • The doctor may or may not give a local anaesthetic to numb the skin.
  • Ultrasound is used to help guide a hollow needle into the amniotic sac through the abdomen
  • A 20 ml sample of amniotic fluid is withdrawn for laboratory analysis.

However in an NACE prenatal test such prolonging procedures are not required. On the onset of the first trimester, fetal DNA information would be available in the maternal plasma. The procedure would be elaborated as:

  • NACE prenatal test kit is requested through a phone call or email
  • On receiving the kit, a maternal 10 ml blood sample is taken
  • Authorized medical personnel would collect the kit with the blood sample
  • Result would be delivered in a week’s time

Thus a singular extraction of peripheral blood (blood from the arm) from the mother is all that is needed, making it absolutely non-invasive and painless; thanks to next generation sequencing technology and advanced bioinformatics analysis.


When Are These Tests Conducted?

Amniocentesis is conducted in the second trimester of gestation that is sometime between 15th and 20th week. Performing the test earlier may result in fetal injury.

NACE pre natal test is ideally done between the 10th and 20th week of gestation. Doctors recommend this NIPT test just shortly before the completion of the first trimester thereby detecting genetic abnormalities in the fetus at the earliest. The earlier is it done it better it is.

Do Such Tests Have Side Effects?

The process of amniocentesis is followed by a whole list of complications. They include:

  • Strenuous activities should be avoided for 24 hours following an amniocentesis
  • Women may feel some cramping during or after the amniocentesis
  • Possible chances of preterm labor and delivery, respiratory distress, postural deformities, chorioamnionitis, fetal trauma and rhesus disease
  • Carries a small risk of miscarriage and fetal infections

The NACE prenatal test is ergonomically designed to detect fetal chromosomal alterations without compromising the health of the mother and baby. Being non-invasive the NIPT test doesn’t pose any threat to the pregnancy. As mentioned before NACE prenatal test resembles a simple blood test. What side-effects could it possibly have?

When Would Test Results Arrive?

The result for amniocentesis is usually received within two weeks which is like a lot of time. Don’t skip the fact that amniocentesis could only be conducted between the 14 and 16th week. The least the patient would want is to get results as early as possible before the 20th week of gestation. Procedures like abortion would not be possible after 20 weeks.

NACE prenatal test not only recommends taking the test as early as the 10th week but also delivers result at your doorstep in 10 days. Cell-free DNA laboratory procedures and report are done in just two days. The new age sequential technology and advanced bioinformatics is what enables this NIPT test stand out.

How Accurate Are The Results?

Though amniocentesis detects chromosomal alterations that points out birth defects, the detection rate of the test ranges between 70-80 % only. False positive rate is another factor that needs to be considered which is as high as 5% in amniocentesis.

The NACE prenatal test not only detects chromosomal disorders like Down’s syndrome, Edward syndrome and Patau syndrome but also assures high specificity rates and sensitivity rates of 99% and 95% respectively. It’s false positive rate in less than 1%.


With the above explanation, the NIPT of NACE definitely proves to be good replacement for painful procedures like amniocentesis. Considering the advance of technology and its benefits, NACE prenatal test is recommended by doctors as a primary screening method for pregnant women.

So what are you waiting for? Talk to your doctor and order the NACE pre natal kit now!!